Physician Assistants pay range in Sioux Falls
New workers and the lowest-paid 10% earn about $106,660 a year or less, while the top 10% make $158,520 or more. The middle half of physician assistants in Sioux Falls earn between $110,150 and $139,120.
- $107K10th
- $110K25th
- $136KMedian
- $139K75th
- $159K90th
median average · bar = middle 50% of workers · how to read it
| Pay level | Per year | Per month | Per hour* |
|---|---|---|---|
| Average | $132,350 | $11,029 | $63.63 |
| Median | $135,790 | $11,316 | $65.28 |
| Entry level (25th percentile) | $110,150 | $9,179 | $52.96 |
| Experienced (75th percentile) | $139,120 | $11,593 | $66.88 |
*Hourly figures assume 2,080 paid hours a year. Hourly to annual salary.
Physician Assistants pay in Sioux Falls vs. South Dakota and the U.S.
Physician assistants in Sioux Falls earn about the same as the South Dakota average ($131,910) and 6% less than the U.S. average ($141,280). At the median the gap is -0% against the U.S. median of $135,880.
| Area | Average | Median | 10th pct. | 90th pct. | Jobs |
|---|---|---|---|---|---|
| Sioux Falls | $132,350 | $135,790 | $106,660 | $158,520 | 290 |
| South Dakota | $131,910 | $133,200 | $104,660 | $158,020 | 680 |
| United States | $141,280 | $135,880 | $99,380 | $190,280 | 162,150 |
State and U.S. rows: BLS statewide and national estimates, May 2025, which include rural areas.
Physician Assistants salary after taxes in Sioux Falls
On the average salary of $132,350, a single filer in Sioux Falls takes home about $101,727 a year, or $8,477 a month and $3,913 every two weeks. Taxes take 23% of gross pay.
The Sioux Falls, SD-MN metro area crosses state lines, so take-home pay depends on the state where you work:
| State | Per year | Per month |
|---|---|---|
| Working in SD | $101,727 | $8,477 |
| Working in MN | $94,171 | $7,848 |
Single filer, standard deduction: federal income tax (2026 brackets), Social Security, Medicare and no state income tax.
Is Sioux Falls a good place for physician assistants? Pay vs. cost of living
Prices in the Sioux Falls area are 9% below the U.S. average (BEA price parity 90.6), so the average $132,350 buys what about $146,032 would buy in a typical U.S. metro. This job pays 2.8 times the median wage of all jobs in Sioux Falls ($47,970). A typical home costs $342,936, or 2.6 years of this average salary before tax.
Physician Assistants salary in other South Dakota cities
Sioux Falls ranks 1st of 2 South Dakota metro areas for this job, the best-paid in the state.
- Sioux Falls$132,350
- Rapid City$129,590
Highest-paying cities for physician assistants
San Jose, CA pays this job the most of the metro areas we cover ($207,660).
- San Jose, CA$207,660
- Salinas, CA$202,320
- San Francisco, CA$182,610
- Vallejo, CA$182,520
- Bakersfield, CA$177,840
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Physician Assistants salary in Sioux Falls: questions
How much do physician assistants make an hour in Sioux Falls?
$63.63 an hour on average, and $65.28 at the median (BLS, May 2025).
What is the entry-level physician assistants salary in Sioux Falls?
The lowest-paid 10% earn about $106,660 a year and the 25th percentile is $110,150, a fair guide to starting pay.
What is the physician assistants take-home pay in Sioux Falls?
About $101,727 a year ($8,477 a month) for a single filer on the average salary of $132,350. South Dakota has no state income tax.
Do physician assistants earn more in Sioux Falls than elsewhere?
The average here is 6% less than the U.S. average for this job ($141,280).
Sources and how to read this page
- Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 29-1071; area Sioux Falls, SD-MN (43620). Relative standard error of the mean wage: 1.5%.
- U.S. and statewide figures: BLS OEWS national and state estimates, May 2025, every employer including rural areas.
- Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.
- Home value: Zillow Home Value Index. Typical-wage figure: OEWS all occupations, same metro.
- Take-home pay: Single filer, standard deduction: federal income tax (2026 brackets), Social Security, Medicare and no state income tax.
- Job concentration: location quotient 1.55, this job is 1.6 times as concentrated as in the U.S. overall.
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