SOC 29-1171 · Jefferson City, MO metro

Nurse Practitioners Salary in Jefferson City, MO

The average salary for nurse practitioners in Jefferson City, Missouri is $124,800 a year ($60.00 an hour), according to BLS estimates for May 2025. The median is $128,710: half of the 130 people in this job in the Jefferson City, MO metro area earn more than that, half earn less. That average is 10% less than the U.S. metro average for this job ($138,268).

$124,800average per year

$60.00 / hourMedian $128,710Take-home ≈ $91,639

  • $103K10th
  • $106K25th
  • $129KMedian
  • $134K75th
  • $153K90th

median average · bar = middle 50% of workers

130people in this job
-10%vs U.S. metro average
#6 of 8Missouri metros
88cost of living (U.S. = 100)
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Nurse Practitioners pay range in Jefferson City

New workers and the lowest-paid 10% earn about $103,470 a year or less, while the top 10% make $153,190 or more. The middle half of nurse practitioners in Jefferson City earn between $105,920 and $133,920.

  • $103K10th
  • $106K25th
  • $129KMedian
  • $134K75th
  • $153K90th

median average · bar = middle 50% of workers

Pay levelPer yearPer monthPer hour*
Average$124,800$10,400$60.00
Median$128,710$10,726$61.88
Entry level (25th percentile)$105,920$8,827$50.92
Experienced (75th percentile)$133,920$11,160$64.38

*Hourly figures assume 2,080 paid hours a year.

Nurse Practitioners salary after taxes in Jefferson City

On the average salary of $124,800, a single filer in Jefferson City takes home about $91,639 a year, or $7,637 a month and $3,525 every two weeks. Taxes take 27% of gross pay.

Single filer, standard deduction: federal income tax (2026 brackets), Social Security, Medicare and state income tax (2026 rules). The 1% earnings tax applies to people who live or work in Kansas City or St. Louis itself, not in the suburbs.

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Is Jefferson City a good place for nurse practitioners? Pay vs. cost of living

Prices in the Jefferson City area are 12% below the U.S. average (BEA price parity 88.0), so the average $124,800 buys what about $141,858 would buy in a typical U.S. metro. This job pays 2.7 times the median wage of all jobs in Jefferson City ($48,030). A typical home costs $275,951, or 2.2 years of this average salary before tax.

See what $124,800 is worth in another city

Nurse Practitioners salary in other Missouri cities

Jefferson City ranks 6th of 8 Missouri metro areas for this job; St. Louis pays the most ($135,550).

All Nurse Practitioners salaries in Missouri

Highest-paying cities for nurse practitioners

San Jose, CA pays this job the most of the metro areas we cover ($225,610).

Nurse Practitioners salary by city

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Reviewed before it counts. Nurse Practitioners in Jefferson City, MO.

Nurse Practitioners salary in Jefferson City: questions

How much do nurse practitioners make an hour in Jefferson City?

$60.00 an hour on average, and $61.88 at the median (BLS, May 2025).

What is the entry-level nurse practitioners salary in Jefferson City?

The lowest-paid 10% earn about $103,470 a year and the 25th percentile is $105,920, a fair guide to starting pay.

What is the nurse practitioners take-home pay in Jefferson City?

About $91,639 a year ($7,637 a month) for a single filer on the average salary of $124,800. The 1% earnings tax applies to people who live or work in Kansas City or St. Louis itself, not in the suburbs.

Do nurse practitioners earn more in Jefferson City than elsewhere?

The average here is 10% less than the U.S. metro average for this job ($138,268).

Sources and how to read this page

  • Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 29-1171; area Jefferson City, MO (27620). Relative standard error of the mean wage: 1.7%.
  • Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.
  • Home value: Zillow Home Value Index. Typical-wage figure: OEWS all occupations, same metro.
  • Take-home pay: Single filer, standard deduction: federal income tax (2026 brackets), Social Security, Medicare and state income tax (2026 rules). The 1% earnings tax applies to people who live or work in Kansas City or St. Louis itself, not in the suburbs.
  • Job concentration: location quotient 0.77, this job is less common than in the U.S. overall (location quotient 0.77).

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