Physician Assistants Salary in South Carolina

Physician assistants in South Carolina earn the most in Spartanburg (average $127,780 a year) and the least in Florence ($113,910), across the 7 South Carolina metro areas we cover. Statewide, BLS puts the physician assistants average at $120,720 and the median at $122,490 for 2,250 workers. The U.S. average for this job is $141,280.

Physician Assistants average salary by city in South Carolina

Spartanburg$127,780
Charleston$123,350
Hilton Head Island$122,000
Myrtle Beach$121,690
Columbia$117,840
Greenville$116,630
Florence$113,910

Pay, take-home pay and cost of living

City	Average	Median	25th pct.	Take-home*	Cost of living
Spartanburg	$127,780	$121,990	$111,680	$92,912	91
Charleston	$123,350	$128,920	$109,960	$90,115	101
Hilton Head Island	$122,000	$125,350	$107,380	$89,263	98
Myrtle Beach	$121,690	$125,700	$101,180	$89,065	94
Columbia	$117,840	$115,840	$107,400	$86,557	94
Greenville	$116,630	$123,310	$96,040	$85,769	93
Florence	$113,910	$120,290	$104,210	$83,997	87

*Average salary after federal and state taxes for a single filer. Cost of living: BEA price parity, U.S. = 100.

Physician Assistants salary in other states

Physician Assistants salary by city and state

More about pay in South Carolina

Sources and how to read this page

Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 29-1071.
U.S. and statewide figures: BLS OEWS national and state estimates, May 2025, every employer including rural areas.
Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.

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