Medical Assistants Salary in South Carolina

Medical assistants in South Carolina earn the most in Charleston (average $43,950 a year) and the least in Florence ($40,640), across the 8 South Carolina metro areas we cover. Statewide, BLS puts the medical assistants average at $42,340 and the median at $41,160 for 12,110 workers. The U.S. average for this job is $46,120.

Medical Assistants average salary by city in South Carolina

Charleston$43,950
Hilton Head Island$43,320
Spartanburg$43,070
Greenville$42,740
Columbia$41,710
Sumter$40,850
Myrtle Beach$40,670
Florence$40,640

Pay, take-home pay and cost of living

City	Average	Median	25th pct.	Take-home*	Cost of living
Charleston	$43,950	$45,600	$38,670	$36,896	101
Hilton Head Island	$43,320	$43,610	$37,530	$36,406	98
Spartanburg	$43,070	$40,930	$38,730	$36,212	91
Greenville	$42,740	$44,860	$37,430	$35,955	93
Columbia	$41,710	$40,680	$37,290	$35,153	94
Sumter	$40,850	$40,780	$35,320	$34,484	88
Myrtle Beach	$40,670	$38,950	$36,780	$34,344	94
Florence	$40,640	$38,790	$36,550	$34,321	87

*Average salary after federal and state taxes for a single filer. Cost of living: BEA price parity, U.S. = 100.

Medical Assistants salary in other states

Medical Assistants salary by city and state

More about pay in South Carolina

Sources and how to read this page

Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 31-9092.
U.S. and statewide figures: BLS OEWS national and state estimates, May 2025, every employer including rural areas.
Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.

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